आय सी एम आर - राष्ट्रीय प्रतिरक्षा रुधिर विज्ञान संस्थान
ICMR-National Institute of Immunohaematology
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आय सी एम आर - राष्ट्रीय प्रतिरक्षा रुधिर विज्ञान संस्थान ICMR-National Institute of Immunohaematology |
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| Ongoing Projects |
| 1 | A comprehensive longitudinal cohort study for organ damage amoung sickle cell disease patients. |
| 2 | Development of indigenous reagent red cell panels for identificaton and characterization of blood group alloantiboides in North East India. |
| 3 | Study of Hemoglobinopathies and G6PD Deficiency among Tribals of Tamilnadu. |
| 4 | National Registry for Rare and other Inherited disorders (NRROID). |
| 5 | Assessment of neonatal screening approaches for Sickle Cell disease and the effect of early intervention in management of the disease in tribal populations. |
| 6 | Training of in-service clinicians from Government Hospitals and outreach programme for aspirational Districts (NANDURBAR) - Screening and Counselling for Genetic Disorders: Incorprorating Prevention of Genetic Disorders in Maternal & Child Health. |
| 7 | Screening, Counseling and awareness for the Prevention of sickle cell Haemoglobinopathies in Tea Garden Communities of Upper Assam |
| 8 | To determine the prevalence of serological and molecular markers of Hepatitis B virus in voluntary blood donors from Maharashtra region (National Health Mission Maharashtra) |
| 9 | National External Quality Assessement for HIV Testing (NACO-MDACS Project) |
| 10 | To explore immune players in Hepatitis B viral infection |
| 11 | Study of Splice Factor mutations and risk assessment in Primary Myelodyspalstic Syndromes. |
| 12 | Study of Clinical and genetic Predictors of Prognosis in Myelodysplastic Syndromes |
| 13 | Incidence of Imatinib resistance and associated BCR-ABL kinase domain mutations among Chronic Myeloid Leukaemia Patients in North East Indian Population |
| 14 | Clinical spectrum and molecular basis of Thrombotic Microangiopathies. |
| 15 | Screening and Laboratory assessment of PWH Registered with HFI |
| 16 | Phenotypic and Genotypic evaluation of Thrombotic Thrombocytopenic Purpura in Indian patients. |
| 17 | Comprehensive genomic and functional evaluation of Factors influencing myocardial infarction in young patients |
| 18 | Longitudinal analysis of Neutralizing and Non neurtralizing antibodies to factor VIII in Hemophilia A patients subclasses, Heterogeneity, Diagnostic and Clinical Implications. |
| 19 | Development of simple novel and rapid diagnostic methods for Glanzmann thrombasthenia |
| 20 | Clinical, Immunological and Molecular characterization of an Autoimmune Lymphoproliferative Syndrome (ALPS) and B-cell expansion with NF?? and T- cell anergy(BENTA) in Indian population. |
| 21 | Comprehensive immune profiling and its correlation with response to therapy and underlying genetic variations in Immune Thrombocytopenia (ITP). |
| 22 | Study on Polio and Non-Polio enterovirus infections in children withimmunodeficiency at multiple medical institutes across India. Phase II |
| 23 | Defining immunological markers for response to therapy in Aplastic Anemia |
| 24 | A non-inferiority randomized trial to assess the efficacy of 10mg hydroxyurea/kg/day versus 20mg hydroxyurea/kg/day in treatment of Sickle cell disease patients of tribal and non-tribal areas in India |
| 25 | Study of micro-RNA expression profile in common variable immunodeficiency disorder |
| 26 | Exploring lymphocyte subsets and cytokine profile in Pediatric Inflammatory Multisystem Syndrome temporally related to SARS-CoV-2 infection (PIMS-TS). (Intramural) |
| 27 | ICMR Task force study on Rational Use of Medicines |
| 28 | To study the role of mitochondrial DNA damage due to iron overload in transfusion dependent Thalassemia major |
| 29 | Identification and molecular characterization of weak D variants among apparently RhD negative individuals from South India (Intramural project in collaboration with JIPMER) |
| 30 | Study of genetic factors and immune parameters focusing on the transmission of HBV in household contacts of classical HBV cases |
| 31 | Exploring immune players in clinical conditions of HBV infection. |
| 32 | Role of endothelial dysfunction and inflammatory process in ineffective erythropoiesis and the clinical severity of hemoglobinopathy patients. |
| 33 | Clinical, Molecular and Cytogenetic Study of Myeloproliferative neoplasms |
| 34 | Study of DNA methylation of Polycomb genes and micro RNAs in Drug Resistance CML patients |
| 35 | Study of genome wide expression profiling of long non coding RNAs (lncRNAs) and mRNA association with myelodysplastic syndromes pathogenesis |
| 36 | Study of molecular pathology of Idiopathic Aplastic Anemia |
| 37 | Understanding the role of epigenetic factors in Fanconi anemia phenotype and cancer Predisposition. |
| 38 | Study of the molecular mechanism of bone marrow failure and cancer risk in Fanconi anemia complementation groups |
| 39 | The role of epigenetic factors in Fanconi anemia phenotype and cancer predisposition |
| 40 | Platelet phenotyping (surface receptors, granules, secretion, and signal transduction) and genotyping of unclassified heritable thrombocytopenia and platelet function disorders. |
| 41 | Generation Sequencing (ICMR Extramural). |
| 42 | Role of Ion Channelopathies in Sickle Cell Disease |
| 43 | To study the role of Regulatory T cells in failure to mount an adequate immune response post-Hepatitis B vaccination |
| 44 | Immune response to precautionary third dose of COVISHIELD/COVAXIN among healthy adult population: an ICMR Cohort study, India |
| 45 | A flow cytometry assay and rapid agglutination test for the detection of anti-FVIII antibodies- SERB |
| 46 | Centre for Product Development: Development of G6PD point of care test (ICMR) |
| 47 | Centre for Product Development: Tranexamic acid combined with recombinant factor VIII for haemophilia patients- (ICMR) |
| 48 | Antibody Profile in post- vaccinated individuals when compared to post-COVID-19 patients |
| 49 | Multi Centric Collaborative Study of the National Registry for Rare Disorders in India- Bleeding disorders |
| 50 | Studies on ABO histo?blood group genes and ACE2 as potential genetic susceptibility factors to SARS-CoV-2 infections: an exploratory study |
| 51 | CRISPR mediated genetic correction of Sickle Cell disease towards clinical trials in a small patient cohort |
| 52 | Study of microRNA expression profile in Common Variable Immunodeficiency disorders (CVID) |
| 53 | A Study on post corona virus disease mucormycosis from Western India, Mumbai. |
| 54 | Strengthening of ICMR-MRUs: Establishment of Autoimmune Diagnostic Laboratories for early detection and management of Autoimmune Disease and empowering MRUs for research in autoimmunity |
| 55 | Role of angiotensin converting enzyme 2 and vitamin D in endothelial dysfunction among COVID-19 patients from Mumbai, Maharashtra |
| 56 | A study to assess the prevalence of Vitamin B12 deficiency in pregnant women in tribal area. |
| 57 | Barriers for Hydroxyurea treatment in sickle cell disease. |
| 58 | Interim Satellite Centre on Haemoglobinopathies at Chandrapur, Maharashtra |
| 59 | Glucose-6-Phosphate Dehydrogenase Deficiency among Three Tribes of Assam, India and its significance for Antimalarial Therapy. |
| 60 | Training of in-service clinicians from Government Hospitals and outreach programme for aspirational Districts - Skill Development in Genetic Diagnosis of Inherited Hematological and Immunological Disorders |
| 61 | Understanding the Genomics of Primary Immune Disorders ( PID) using Next Generation Sequencing (NGS). |
| 62 | Immuno-profiling Consortium- Integration of Extended Immune Monitoring (ExImM) and clinical parameters for early prediction of disease trajectory/progression, treatment planning, and prophylaxis to improve COVID-19 prognosis. |
| 63 | Center of Excellence for Research, Diagnosis, and Management of Primary Immunodeficiency Disorders (PID). |
| 64 | FPID-NIIH Regional Diagnostic Centre for Primary Immunodeficiency Diseases |
| 65 | Radiation Sensitivity Assessment In Inborn Erroras Of Immunity ( IEI ) Patients with Actinopathies |
| 66 | Studies on the role of CD47/SIRP?-interaction in regulation of erythrophagocytosis |
| 67 | Molecular studies of Keap1-Nrf2 signalling axis in the pathophysiology of Sickle cell disease: an exploratory study |
| 68 | Prevalence and Molecular Characterization of NADH Cytochrome B5 reductase deficiency in India. |
| 69 | Molecular Characterization of unexplained cases of congenital anaemia using next generation sequencing panel. |
| 70 | Congenital Dyserythropoietic Anemias: Molecular Diagnosis and Diagnostic Approach in a Cohort of Indian Patients |
| 71 | Role of Ion Channelopathies in Sickle Cell Disease |
| 72 | Simple APTT Based Tests for Differential Diagnsis of Hemophilia A & B. |
| 73 | Centre of Excellence for Advanced Research in Immunohaematology and Transfusion Medicine and create a National Rare Donor Registry. |
| 74 | Use of advanced genomics in solving complex serological problems in a Transfusion setting. |
| 75 | Identification of molecular signarure ( genetic variants) influencing the phenotypic diversity in beta-hemoglobinopathies by genome wide association studies |
| 76 | Risk factors for Covid Associated Mucormycosis in India: A case control investigation. |
| 77 | A multicentric study on Systemic Lupus Erythematous (SLE) from the North Eastern Region of India: Early diagnosis to research potential for understanding disease pathogenesis. |
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