Department of Transfusion Medicine

Projects

Completed Projects:

  1. Application of ELISA in Blood Group Serology for the detection of weaker variants of A and B blood groups.
  2. Anti-idiotype studies in Rh D negative women
  3. C1q uptake by Rh antibodies
  4. Clinical significance of complement uptake in ABO-HDN.
  5. Functional offinity constant of Rh HDN.
  6. Follow up of Rh D negative women receiving anti-D immunoglobulin contaminated with anti-HIV.
  7. Origin and distribution of Bombay Blood Groups in India.
  8. Study of structure and sequential expression of ABH antigen in health and malignancy.
  9. Intra uterine transfusion in server Rh allo-immunisation.
  10. Immunological profile in cases of AIHA.
  11. Population screening for detection and molecular characterization of particle D antigens and Rh variants and its clinical applications.
  12. Cryopreservations of red cells.
  13. Molecular characterization of Bombay and para Bombay phenotypes.
  14. Rh (D) epitope density profile of Rh D variant red cells analysed by flowcytometry.
  15. Anti-D quantitation in Rh (D) immunized women by flow cytometric method.
  16. National Repository on Cryopreservation facility and research
    Year of Commencement: 1997
    Duration: 3 years
    Funding Agency: Department of Biotechnology ( New Delhi)
    Outcome:
    Cryopreservation of red cells at -80 oC using high concentration glycerol technique was experimented with samples collected from voluntary blood donors. Biochemical, haematological and red cell antigen strength evaluated before preservation and after thawing and washing on these samples showed good results. Rare blood donor units can be preserved using this method which will be useful for patients requiring the same rare donor types.
  17. Molecular characteization of ABO bood group antigens in the Indian population.

On going Projects

  1. Identification of rare blood groups in the donor population.
  2. Serological characterization of partial D variants amongst the Rh(D) negative women and amongst the Rh D discrepant grouping cases reported.