Department of Hematogenetics

Name: Dr. Prabhakar S. Kedar

Designation: Technical Officer A

E mail : kedarps2002@yahoo.com

Educational Qualification:

International Fellowship and visits

• Awarded fellowship for JSPS-DST RONPAKU (Dissertation PhD from Japan) Programme -2004-2008 (5yrs) by Japan Society for Promotion of Science, Tokyo at Kyushu Institute Of Technology, Fukuoka Japan.

• Under JSPS Ronpaku fellowship, attended training programme at Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women’s Medical University. Tokyo , Japan from June 19 to July 15 2006.
• Participated in the 49 th Annual meeting of American Society of Hematology (ASH) held at Georgia World Congress Center , Atlanta, Georgia, USA , period 6-11 th December 2007

Fellowships/Awards

• Awarded ICMR International fellowship for Young Biomedical Scientist -2010 program. (Period 1 st February 2010 to 31 st August 2010: Six Months under the guidence of f Prof. Seth L. Alper, M.D.,Ph.D. Professor of Medicine, Harvard Medical School Beth Israel Deaconess Medical. Center. 330, Brookline Aveneue Boston, MA 02155 USA at Harvard Medical School Boston, USA. )
• Participated and Presented paper entitled “ Molecular characterization of the PKLR gene in eighteen pyruvate kinase deficient Indian patients.” at 49 th Annual conference of American Society of Hematology held at Atlanta, Georgia , USA , period 6-11 th December 2007 sponsored by Mumbai Haematology Group, Mumbai as a First Prize for Best Paper Award
• ASH Meeting ( USA) sponsorship Award for best research paper entitled “ A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type-I recessive hereditary methemoglobinemia. ’ presented at Annual Conference of Mumbai Hematology Group at Tata Memorial Hospital. Mumbai on 8 th to 16 th Oct 2007 .
• Ronpaku Gold Medal for PhD Thesis awarded by Japan Society of Promotion of science, Tokyo under DST-JSPS RONPAKU Fellowship-2007.
• Awarded best research paper entitled “ A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type-I recessive hereditary methemoglobinemia. ’ presented at Annual Conference of Mumbai Hematology Group at Tata Memorial Hospital. Mumbai on 8 th to 16 th Oct 2007 .
• Awarded Best Research Paper award “ Eosin 5’ maleimide as a diagnostic tool for Red cell membrane cytoskeleton Disorders”: J C Patel Award Session 27 th Annual Conference of Bombay Hematology Group at Tata Memorial Hospital. Mumbai, 15 th to 16 th Feb 2003.
• Department of Science and Technology (DST) New Delhi awarded JSPS (RONPAKU) fellowship for Doctor of Philosophy (PhD) from Japan in year 2003.
• Awarded Hindi Diploma in First Division with distinction conducted by Central Hindi Directorate. New Delhi (1995).
• Best paper award by Mumbai Hematology Group, Mumbai

Fields of Interest: Red cell enzymopathies, Red cell membrane defects, Methemoglobinemia, Haemoglobinopathies, Gene and protein expression study.

Publications:

Chapters in Books/Monographic: 2

International Journals: 18

National Journal: 6

International abstracts: 1

National abstracts: 24

Latest 10 Publications:

1. Andrew K. Stewart*, Prabhakar S. Kedar*, Boris E. Shmukler, David H. Vandorpe, Bertil Glader, Alicia Rivera, Carlo Brugnara, Seth L. Alper: Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis American Journal of Physiology and Cell Physiology 2011 May;300(5):C1034-46.
2. Prashant Warang, Maya Gupta, Prabhakar Kedar, Kanjaksha Ghosh, Roshan Colah.: Flow cytometric osmotic fragility – An effective screening approach for red cell membranopathies. Cytometry: Part B - Clinical Cytometry – 2011 May;80(3):186-90
3. Prabhakar S. Kedar, Prashant Warang , K. Ghosh, Roshan B. Colah, Severe mental retardation and recessive congenital methemoglobinemia in three Indian patient’s compound heterozygous for NADH-Cytochrome b5 reductase gene mutations. American Journal of Hematology, 2011 Mar;86(3):327-9. (Impact Factor-2.60)
4. Boris E. Shmukler, Prabhakar S. Kedar, Prashant Warang, Mukesh Desai, Manisha Madkaikar, Kanjaksha Ghosh, Roshan B. Colah, and Seth L. Alper : Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. American Journal of Hematology, 2010:85:824-828.
5. Kedar P, Hamada T, Warang P, Nadkarni A, Shimizu K, Fujji H, Ghosh K, Kanno H, Colah R.: Eleven novel mutations in the PK-LR gene in eighteen pyruvate kinase deficient Indian patients with heterogeneous clinical phenotypes. Papers presented at conferences. Clinical Genetics : 2008; Aug 28. [Epub ahead of print]
6. Chalvam R, Kedar PS, Colah RB, Ghosh K, Mukherjee M: A novel mutation R198H in the Glucose 6-phosphate dehydrogenase gene in the tribal groups of the Nilgiris in Southern India. Journal of Human Genetics 2008; 53: 181-184.
7. Prabhakar S. Kedar , Prashant Warang , Anita H Nadkarni,K. Ghosh, Roshan B. Colah, A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type-I recessive hereditary methemoglobinemia. Blood Cells Molecules and Disease; 2008:40; 323–327.
8. Prabhakar S. Kedar , Roshan Colah, Kazuyuki Shimizu: A proteomic approach to study the pyk-F gene knockout on the metabolic regulation of Aromatic amino acid biosynthetic pathway in Escherichia coli. Enzyme and Microbial Technology,  2007; 41 ;455-465.
9. Prabhakar S. Kedar, S. Nampoothiri , S. Sreedhar , K. Ghosh . K. Shimizu, H. Kanno, R. B. Colah: First Trimester Prenatal Diagnosis of Pyruvate Kinase Deficiency in an Indian family with the PK –Amish mutation. Genetics and Molecular Research, 2007;6;370-375.
10. Neerja Gupta , Paola Bianchi , Elisa Fermo, Madhulika Kabra , Prashant Warang, Prabhakar S. Kedar, Nomeeta Gupta Roshan Colah: Prenatal diagnosis for a novel homozygous mutation in PKLR gene in an Indian family. Prenatal Diagnosis 2006:27:117-118.