Department of Transfusion Transmitted Diseases
Projects
Completed projects
1. Title: Evaluation of Jothi Amritham a herbal preparation for HIV treatment
Year of commencement: 2005-2007
Duration : 2 years
Funding agency: NACO - JJ Hospital Mumbai
Outcome : Around 258 patients were enrolled for the trial, the CD4, CD8 counts and viral load have been established during periodic intervals. The viral load showed decrease during the therapy
2. Title: Evaluation of Receptol for HIV treatment
Year of commencement: 2005-2007
Duration : 2 years
Funding agency: NACO - Sion Hospital Mumbai
Outcome : Around 75 patients were enrolled for the trial, the CD4, CD8 counts and viral load have been established during periodic intervals of follow-up. The viral load showed decrease during the therapy
3. Title: HLA distribution in HIV positive antiretroviral treated patients from Mumbai.
Year of commencement: 2008
Duration: 1 year
Funding agency: NIIH - KEM Hospital
Outcome: HLA A2 and HLA B8 alleles were significantly associated, while HLA B5 and HLA B37 were protected among the HIV-1 infected individuals who were on primary line of Antiretroviral Treatment. Among the total patients investigated we found that 64.81% had history of TB, while 31.48% had a history of Herpes Zoster and 3.75% had Diabetes Mellitus. 43.9% of the spouses were found to be seropositive among the patients studied.
4. Title: CCR5 distribution in HIV positive antiretroviral treated patients from Mumbai.
Year of commencement: 2009-10
Duration: 1 year
Funding agency: NIIH - KEM Hospital
Outcome: A total of 153 HIV-1 infected patients confirmed for their HIV-1 status were studied. A total of 68 normal Healthy individuals from the same ethnic background confirmed negative for their HIV-1 status were studied. Genomic DNA from patients and controls were extracted and amplified for CCR5 gene segment using PCR. Amplified products were analyzed on 12% acrylamide gel, which yielded an 189bp fragment for wild type allele and 157bp fragment for the deleted (mutant) allele. Results: Our analysis revealed that 7.19% were homozygous ,0.65% were heterozygous and the remaining 92.16% had no deletion for ∆32 allele among the infected subjects.10.29% were homozygous ,0.00% were heterozygous and the remaining 89.71% had no deletion for ∆32 allele among the control subjects. Conclusion: Our study reveals that the CCR5 allele frequency varies in different ethnic groups studied. Around 7.84% of the Patients have not been protected though they have the presence of the 32bp deletion
Ongoing Projects:
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