Discoveries and Innovations

  1. Discovery of “ Bombay ” blood group.
  2. Discovery of novel LDH variant in association with HBsAg.
  3. Discovery of Indian (Inª) blood group.
  4. Detection of rare antigens like M g, I-i-, Ry, Rz alleles, Co(a-b-), homozygous D.
  5. Detection of novel and rare hemoglobin variants like Hb D- Agri, HbM- Ratnagiri respectively.
  6. Detection of G6PD variants like G6PD–Insuli, G6PD–Rohini, G6PD-Jamnagar, G6PD–Namaru , G6PD- Nilgiri.
  7. Detection of several novel and rare β-thalassemia mutations.
  8. First case of vitamin K dependent coagulation factors deficiency from India .
  9. Protective effect of EACA (Epsilon Amino Caproic Acid) on factor VIII inhibitor dependent destruction of factor VIII.
  10. Detection of novel mutations in Glanzmann’s thrombasthenia.
  11. Correlation between chronic synovitis and HLA B 27 in patients with severe hemophilia.
  12. Gene mapping of new marker chromosome using FISH.
  13. Novel translocation in MDS ( Myelo Dysplastic Syndrome ).
  14. Novel HLA alleles in patients with seronegative spondarthritis, hemophilia and leprosy.
  15. HLA association with ANCA (Anti Neutrophil Cytoplasmic Antibodies) patients.
  16. Identified several novel mutations causing coagulation factor deficiencies (factor IX, factor VII, factor X) and protein C gene.
  17. Indigenous production of monoclonal antibodies against A and B blood group antigens, fetal hemoglobin (HbF), Factor VIII.
  18. Development of an ELISA assay for factor VIII antibody.
  19. Development of ELISA for identification of weaker variants of A and B.
  20. Development of ELISAs for C1q, ANA, anti-id, anti-Histone antibodies.